microRNA-221 Inhibits Latent TGF-β1 Activation through Targeting Thrombospondin-1 to Attenuate Kidney Failure-Induced Cardiac Fibrosis
Kidney failure (KF) is associated with cardiac fibrosis and significantly increased mortality in heart failure. Thrombospondin-1 (TSP1), a key regulator of latent transforming growth factor-β1 (L-TGF-β1) activation, is a predicted target of miR-221. We hypothesized miR-221 attenuates severe KF-assoc...
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| Main Authors: | , , , |
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| Format: | Book |
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Elsevier,
2020-12-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |