Convergent synthesis of new N -substituted 2-{[5-(1H -indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as suitable therapeutic agents

• Main Authors: Kaniz Rubab (Author), Muhammad Athar Abbasi (Author), Aziz- (Author), Sabahat Zahra Siddiqui (Author), Muhammad Ashraf (Author), Ayesha Shaukat (Author), Irshad Ahmad (Author), Muhammad Arif Lodhi (Author), Farman Ali Khan (Author), Muhammad Shahid (Author), Muhammad Nadeem Akhtar (Author)
• Format: Book
• Published: Universidade de São Paulo, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

abstract A series of N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides (8a-w) was synthesized in three steps. The first step involved the sequential conversion of 2-(1H-indol-3-yl)acetic acid (1) to ester (2) followed by hydrazide (3) formation and finally cyclizatio...