Convergent synthesis of new N -substituted 2-{[5-(1H -indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as suitable therapeutic agents

• Auteurs principaux: Kaniz Rubab (Auteur), Muhammad Athar Abbasi (Auteur), Aziz- (Auteur), Sabahat Zahra Siddiqui (Auteur), Muhammad Ashraf (Auteur), Ayesha Shaukat (Auteur), Irshad Ahmad (Auteur), Muhammad Arif Lodhi (Auteur), Farman Ali Khan (Auteur), Muhammad Shahid (Auteur), Muhammad Nadeem Akhtar (Auteur)
• Format: Livre
• Publié: Universidade de São Paulo, 2015-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

abstract A series of N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides (8a-w) was synthesized in three steps. The first step involved the sequential conversion of 2-(1H-indol-3-yl)acetic acid (1) to ester (2) followed by hydrazide (3) formation and finally cyclizatio...