Investigation of a fully mechanistic physiologically based pharmacokinetics model of absorption to support predictions of milk concentrations in breastfeeding women and the exposure of infants: A case study for albendazole

• Principais autores: Susan Cole (Autor), Maria Malamatari (Autor), Andrew Butler (Autor), Mahnoor Arshad (Autor), Essam Kerwash (Autor)
• Formato: Livro
• Publicado em: Wiley, 2024-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Due to limited non‐clinical and clinical data, European guidance recommends to discontinue breastfeeding when taking albendazole. The aim of this study was to consider the use of PBPK modeling to support the expected exposure in breastfed infants. A fully mechanistic PBPK approach was used...