Investigation of a fully mechanistic physiologically based pharmacokinetics model of absorption to support predictions of milk concentrations in breastfeeding women and the exposure of infants: A case study for albendazole

• मुख्य लेखकों: Susan Cole (लेखक), Maria Malamatari (लेखक), Andrew Butler (लेखक), Mahnoor Arshad (लेखक), Essam Kerwash (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Due to limited non‐clinical and clinical data, European guidance recommends to discontinue breastfeeding when taking albendazole. The aim of this study was to consider the use of PBPK modeling to support the expected exposure in breastfed infants. A fully mechanistic PBPK approach was used...