Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism

• Main Authors: Priscila Hess Lopes (Author), Mário T. Murakami (Author), Fernanda C. V. Portaro (Author), Kerly Fernanda Mesquita Pasqualoto (Author), Carmen van den Berg (Author), Denise V. Tambourgi (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loxosceles spiders' venoms consist of a mixture of proteins, including the sphingomyelinases D (SMases D), which are the main toxic components responsible for local and systemic effects in human envenomation. Herein, based on the structural information of SMase D from Loxosceles laeta spider ve...