Targeting Loxosceles spider Sphingomyelinase D with small-molecule inhibitors as a potential therapeutic approach for loxoscelism

• Автори: Priscila Hess Lopes (Автор), Mário T. Murakami (Автор), Fernanda C. V. Portaro (Автор), Kerly Fernanda Mesquita Pasqualoto (Автор), Carmen van den Berg (Автор), Denise V. Tambourgi (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Loxosceles spiders' venoms consist of a mixture of proteins, including the sphingomyelinases D (SMases D), which are the main toxic components responsible for local and systemic effects in human envenomation. Herein, based on the structural information of SMase D from Loxosceles laeta spider ve...