Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer's disease pathology in mice

• मुख्य लेखकों: Christiana Bjorkli (लेखक), Mary Hemler (लेखक), Joshua B. Julian (लेखक), Axel Sandvig (लेखक), Ioanna Sandvig (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

All drug trials completed to date have fallen short of meeting the clinical endpoint of significantly slowing cognitive decline in Alzheimer's disease (AD) patients. In this study, we repurposed two FDA-approved drugs, Fasudil and Lonafarnib, targeting synaptic formation (i.e., Wnt signaling) a...