3,4-Methylenedioxy-β-Nitrostyrene Alleviates Dextran Sulfate Sodium-Induced Mouse Colitis by Inhibiting the NLRP3 Inflammasome

• Main Authors: Juanjuan Zheng (Author), Zhongxin Jiang (Author), Yue Song (Author), Shu Huang (Author), Yuzhang Du (Author), Xiaobao Yang (Author), Yan Xiao (Author), Zhihui Ma (Author), Dakang Xu (Author), Jing Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory bowel disease (IBD) has been reported to be associated with NLRP3 inflammasome activation. Therefore inhibiting inflammasome activation could be a new approach to treat IBD. Inflammasome inhibitors NLRP3-IN-2, JC124, and 3,4-methylenedioxy-β-nitrostyrene (MNS) were previously reported t...