The In Vivo Granulopoietic Response to Dexamethasone Injection Is Abolished in Perforin-Deficient Mutant Mice and Corrected by Lymphocyte Transfer from Nonsensitized Wild-Type Donors

• Main Authors: Pedro Xavier-Elsas (Author), Cássio Luiz Coutinho Almeida da Silva (Author), Bruno Marques Vieira (Author), Daniela Masid- (Author), Túlio Queto (Author), Bianca de Luca (Author), Thiago Soares de Souza Vieira (Author), Maria Ignez C. Gaspar-Elsas (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Exogenously administered glucocorticoids enhance eosinophil and neutrophil granulocyte production from murine bone-marrow. A hematological response dependent on endogenous glucocorticoids underlies bone-marrow eosinophilia induced by trauma or allergic sensitization/challenge. We detected a defect i...