VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy

• Váldodahkkit: Lijuan Wen (Dahkki), Yanan Tan (Dahkki), Suhuan Dai (Dahkki), Yun Zhu (Dahkki), Tingting Meng (Dahkki), Xiqin Yang (Dahkki), Yupeng Liu (Dahkki), Xuan Liu (Dahkki), Hong Yuan (Dahkki), Fuqiang Hu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The existence of blood-brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM i...