VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy

• Autori principali: Lijuan Wen (Autore), Yanan Tan (Autore), Suhuan Dai (Autore), Yun Zhu (Autore), Tingting Meng (Autore), Xiqin Yang (Autore), Yupeng Liu (Autore), Xuan Liu (Autore), Hong Yuan (Autore), Fuqiang Hu (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

The existence of blood-brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM i...