VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy

• Autores principales: Lijuan Wen (Autor), Yanan Tan (Autor), Suhuan Dai (Autor), Yun Zhu (Autor), Tingting Meng (Autor), Xiqin Yang (Autor), Yupeng Liu (Autor), Xuan Liu (Autor), Hong Yuan (Autor), Fuqiang Hu (Autor)
• Formato: Libro
• Publicado: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The existence of blood-brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM i...