VEGF-mediated tight junctions pathological fenestration enhances doxorubicin-loaded glycolipid-like nanoparticles traversing BBB for glioblastoma-targeting therapy

• Main Authors: Lijuan Wen (Author), Yanan Tan (Author), Suhuan Dai (Author), Yun Zhu (Author), Tingting Meng (Author), Xiqin Yang (Author), Yupeng Liu (Author), Xuan Liu (Author), Hong Yuan (Author), Fuqiang Hu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The existence of blood-brain barrier (BBB) greatly hindered the penetration and accumulation of chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. The growth of GBM supervene the impairment of tight junctions (TJs); however, the pathogenesis of BBB breakdown in GBM i...