Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

• Главные авторы: Huaqiang Tao (Автор), Yunxia Tao (Автор), Chen Yang (Автор), Wenming Li (Автор), Wei Zhang (Автор), Xueyan Li (Автор), Ye Gu (Автор), Yujing Hong (Автор), Huilin Yang (Автор), Yu Liu (Автор), Xing Yang (Автор), Dechun Geng (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Предметы: article
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Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus res...