Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

• Main Authors: Huaqiang Tao (Author), Yunxia Tao (Author), Chen Yang (Author), Wenming Li (Author), Wei Zhang (Author), Xueyan Li (Author), Ye Gu (Author), Yujing Hong (Author), Huilin Yang (Author), Yu Liu (Author), Xing Yang (Author), Dechun Geng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus res...