Ultrasound Assisted Exosomal Delivery of Tissue Responsive mRNA for Enhanced Efficacy and Minimized Off-Target Effects

• 主要な著者: Wenqi Sun (著者), Changyang Xing (著者), Lianbi Zhao (著者), Ping Zhao (著者), Guodong Yang (著者), Lijun Yuan (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2020-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Exosome-mediated nucleic acids delivery has been emerging as a promising strategy for gene therapy. However, the intrinsic off-target effects due to non-specific uptake of exosomes by other tissues remain the big hurdle for clinical application. In this study, we aimed to enhance the efficacy and mi...