Ultrasound Assisted Exosomal Delivery of Tissue Responsive mRNA for Enhanced Efficacy and Minimized Off-Target Effects

• Egile Nagusiak: Wenqi Sun (Egilea), Changyang Xing (Egilea), Lianbi Zhao (Egilea), Ping Zhao (Egilea), Guodong Yang (Egilea), Lijun Yuan (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2020-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Exosome-mediated nucleic acids delivery has been emerging as a promising strategy for gene therapy. However, the intrinsic off-target effects due to non-specific uptake of exosomes by other tissues remain the big hurdle for clinical application. In this study, we aimed to enhance the efficacy and mi...