Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells

• Main Authors: Maroua Mbarik (Author), Samuel J. Poirier (Author), Jérémie Doiron (Author), Ayyoub Selka (Author), David A. Barnett (Author), Marc Cormier (Author), Mohamed Touaibia (Author), Marc E. Surette (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract 5‐lipoxygenase (5‐LO) catalyzes the biosynthesis of leukotrienes, potent lipid mediators involved in inflammatory diseases, and both 5‐LO and the leukotrienes are validated therapeutic targets. Caffeic acid phenethyl ester (CAPE) is an effective inhibitor of 5‐LO and leukotriene biosynthesi...