Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment

• Main Authors: Ruiming Zhang (Author), Chuanyue Gao (Author), Mingxing Hu (Author), Xingxing Wang (Author), Shuoyuan Li (Author), Zhenmei An (Author), Xifei Yang (Author), Yongmei Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Chrysin (5,7-dihydroxyflavone) is a natural flavonoid that has been reported as a potential treatment for non-alcoholic fatty liver disease (NAFLD). However, extensive phase II metabolism and poor aqueous solubility led to a decrease in the chrysin concentration in the blood after oral a...