Design, synthesis, and biological evaluation of biotinylated colchicine derivatives as potential antitumor agents

• Main Authors: Chao Wang (Author), Yujing Zhang (Author), Zeyu Wang (Author), Yuelin Li (Author), Qi Guan (Author), Dongming Xing (Author), Weige Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemical drug design based on the biochemical characteristics of cancer cells has become an important strategy for discovering new anti-tumour drugs to improve tumour targeting effects and reduce off-target toxicities. Colchicine is one of the most prominent and historically microtubule-targeting dr...