Targeted delivery of β-carotene potentially prevents blood-brain barrier breakdown after stroke in mice

• Autori principali: Qaisar Mahmood (Autore), Nan-Nan Lu (Autore), Xiao-Juan Wang (Autore), Yong-Zhong Du (Autore), Muhammad Usman Ghori (Autore), Bing Tian (Autore), Hong-Yu Yang (Autore), Feng Han (Autore), Guo-Jun Jiang (Autore), Ying-mei Lu (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background: After an acute stroke, highly reactive oxygen and nitrogen species (ROS/RNS) lead to microvessel injury and inhibit endogenous mediators to prevent the repair process of endothelial dysfunction and tissue injury. Among them, the peroxynitrite (ONOO−) generation as a result of nitric oxid...