Targeted delivery of β-carotene potentially prevents blood-brain barrier breakdown after stroke in mice

• Main Authors: Qaisar Mahmood (Author), Nan-Nan Lu (Author), Xiao-Juan Wang (Author), Yong-Zhong Du (Author), Muhammad Usman Ghori (Author), Bing Tian (Author), Hong-Yu Yang (Author), Feng Han (Author), Guo-Jun Jiang (Author), Ying-mei Lu (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: After an acute stroke, highly reactive oxygen and nitrogen species (ROS/RNS) lead to microvessel injury and inhibit endogenous mediators to prevent the repair process of endothelial dysfunction and tissue injury. Among them, the peroxynitrite (ONOO−) generation as a result of nitric oxid...