Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

The poor solubility and permeability of compounds beyond Lipinski's Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of important questions addressing food effects is...

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Main Authors: Dong Ye (Author), Álvaro López Mármol (Author), Verena Lenz (Author), Patricia Muschong (Author), Anita Wilhelm-Alkubaisi (Author), Manuel Weinheimer (Author), Mirko Koziolek (Author), Kerstin A. Sauer (Author), Loic Laplanche (Author), Mario Mezler (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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