Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

• Egile Nagusiak: Dong Ye (Egilea), Álvaro López Mármol (Egilea), Verena Lenz (Egilea), Patricia Muschong (Egilea), Anita Wilhelm-Alkubaisi (Egilea), Manuel Weinheimer (Egilea), Mirko Koziolek (Egilea), Kerstin A. Sauer (Egilea), Loic Laplanche (Egilea), Mario Mezler (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The poor solubility and permeability of compounds beyond Lipinski's Rule of Five (bRo5) are major challenges for cell-based permeability assays. Due to their incompatibility with gastrointestinal components in biorelevant media, the exploration of important questions addressing food effects is...