Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.

• Hoofdauteurs: Thanavadee Prachason (Auteur), Kanittha Konhan (Auteur), Piyapat Pongnarin (Auteur), Somruedee Chatsiricharoenkul (Auteur), Yupin Suputtamongkol (Auteur), Chanin Limwongse (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

BACKGROUND: Our earlier genome-wide expression study revealed up-regulation of a tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO1), in patients with scrub typhus. This gene has been previously reported to have anti-microbial activity in a variety of infectious diseases; therefore, w...