Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi.

• मुख्य लेखकों: Thanavadee Prachason (लेखक), Kanittha Konhan (लेखक), Piyapat Pongnarin (लेखक), Somruedee Chatsiricharoenkul (लेखक), Yupin Suputtamongkol (लेखक), Chanin Limwongse (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BACKGROUND: Our earlier genome-wide expression study revealed up-regulation of a tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase (IDO1), in patients with scrub typhus. This gene has been previously reported to have anti-microbial activity in a variety of infectious diseases; therefore, w...