Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression

• Main Authors: Wei Jiang (Author), Guosheng Gu (Author), Yumin Zhang (Author), Yushuai Song (Author), Ming Shi (Author), Gang Wang (Author), Huizhong Li (Author), Tingting Tao (Author), Jianhua Qin (Author), Xianliang Li (Author), Hongtao Jia (Author), Feng Jiao (Author), Weidong Xu (Author), Xiaoyi Huang (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The design of chimeric antigen receptors (CAR) significantly enhances the antitumor efficacy of T cells. Although some CAR-T products have been approved by FDA in treating hematological tumors, adoptive immune therapy still faces many difficulties and challenges in the treatment of solid tumors. In...