A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

• Päätekijät: Yao eChen (Tekijä), Jessica Lizette Saulnier (Tekijä), Gary eYellen (Tekijä), Bernardo eSabatini (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Neuromodulators have profound effects on behavior, but the dynamics of their intracellular effectors has remained unclear. Most neuromodulators exert their function via G-protein-coupled receptors (GPCRs). One major challenge for understanding neuromodulator action is the lack of dynamic readouts of...