A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging

• Автори: Yao eChen (Автор), Jessica Lizette Saulnier (Автор), Gary eYellen (Автор), Bernardo eSabatini (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Neuromodulators have profound effects on behavior, but the dynamics of their intracellular effectors has remained unclear. Most neuromodulators exert their function via G-protein-coupled receptors (GPCRs). One major challenge for understanding neuromodulator action is the lack of dynamic readouts of...