Mitofusin 2 Promotes Apoptosis of CD4+ T Cells by Inhibiting Autophagy in Sepsis

• Main Authors: Lan Ying (Author), Guang-Ju Zhao (Author), You Wu (Author), He-Liang Ke (Author), Guang-Liang Hong (Author), Hui Zhang (Author), Ning Dong (Author), Yao Wu (Author), Yong-Ming Yao (Author), Zhong-Qiu Lu (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apoptosis of CD4+ T cells is a primary pathophysiological mechanism of immune dysfunction in the pathogenesis of sepsis. Mitofusin 2 (Mfn2), an integral mitochondrial outer membrane protein, has been confirmed to be associated with cellular metabolism, proliferation, and apoptosis. The function of M...