Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates

• Main Authors: Tomohiro Fujii (Author), Calliste Reiling (Author), Colette Quinn (Author), Michal Kliman (Author), Brian A. Mendelsohn (Author), Yutaka Matsuda (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP-HPLC), size exclusion chromatography HPLC (SEC-HPLC...