Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates

• Autors principals: Tomohiro Fujii (Autor), Calliste Reiling (Autor), Colette Quinn (Autor), Michal Kliman (Autor), Brian A. Mendelsohn (Autor), Yutaka Matsuda (Autor)
• Format: Llibre
• Publicat: Open Exploration Publishing Inc., 2021-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP-HPLC), size exclusion chromatography HPLC (SEC-HPLC...