Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates

• Hlavní autoři: Tomohiro Fujii (Autor), Calliste Reiling (Autor), Colette Quinn (Autor), Michal Kliman (Autor), Brian A. Mendelsohn (Autor), Yutaka Matsuda (Autor)
• Médium: Kniha
• Vydáno: Open Exploration Publishing Inc., 2021-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Aim: Direct analytical comparison of two major drug-linkers in the antibody-drug conjugate (ADC) field was conducted. Methods: Four different analytical methods [AlogP calculation, reverse phase (RP) high-performance liquid chromatography (HPLC; RP-HPLC), size exclusion chromatography HPLC (SEC-HPLC...