Targeting G-quadruplexes with Organic Dyes: Chelerythrine-DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

• Main Authors: Alessio Terenzi (Author), Hugo Gattuso (Author), Angelo Spinello (Author), Bernhard K. Keppler (Author), Christophe Chipot (Author), François Dehez (Author), Giampaolo Barone (Author), Antonio Monari (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences—representative of different topologies and possessing biological...