Targeting G-quadruplexes with Organic Dyes: Chelerythrine-DNA Binding Elucidated by Combining Molecular Modeling and Optical Spectroscopy

• मुख्य लेखकों: Alessio Terenzi (लेखक), Hugo Gattuso (लेखक), Angelo Spinello (लेखक), Bernhard K. Keppler (लेखक), Christophe Chipot (लेखक), François Dehez (लेखक), Giampaolo Barone (लेखक), Antonio Monari (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2019-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The DNA-binding of the natural benzophenanthridine alkaloid chelerythrine (CHE) has been assessed by combining molecular modeling and optical absorption spectroscopy. Specifically, both double-helical (B-DNA) and G-quadruplex sequences—representative of different topologies and possessing biological...