Carbon Nanotubes-Potent Carriers for Targeted Drug Delivery in Rheumatoid Arthritis

• Main Authors: Camilla Kofoed Andersen (Author), Sangita Khatri (Author), Jonas Hansen (Author), Sofie Slott (Author), Rohith Pavan Parvathaneni (Author), Ana C. Mendes (Author), Ioannis S. Chronakis (Author), Shu-Chen Hung (Author), Narendiran Rajasekaran (Author), Zhuoran Ma (Author), Shoujun Zhu (Author), Hongjie Dai (Author), Elizabeth D. Mellins (Author), Kira Astakhova (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two types of single-walled carbon nanotubes (SWCNTs), HiPco- and carboxyl-SWCNT, are evaluated as drug carriers for the traditional anti-inflammatory drug methotrexate (MTX) and a small interfering RNA (siRNA) targeting NOTCH1 gene. The nanotubes are solubilized by PEGylation and covalently loaded w...