The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy
Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...
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The Company of Biologists,
2011-07-01T00:00:00Z.
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