The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy

• Auteurs principaux: James N. Sleigh (Auteur), Thomas H. Gillingwater (Auteur), Kevin Talbot (Auteur)
• Format: Livre
• Publié: The Company of Biologists, 2011-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Spinal muscular atrophy (SMA), which is caused by inactivating mutations in the survival motor neuron 1 (SMN1) gene, is characterized by loss of lower motor neurons in the spinal cord. The gene encoding SMN is very highly conserved in evolution, allowing the disease to be modeled in a range of speci...