Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• المؤلفون الرئيسيون: Nhu Truong (مؤلف), Andrea L. Cottingham (مؤلف), Shruti Dharmaraj (مؤلف), Jacob R. Shaw (مؤلف), Jackline Joy Martin Lasola (مؤلف), Christopher C. Goodis (مؤلف), Steven Fletcher (مؤلف), Ryan M. Pearson (مؤلف)
• التنسيق: كتاب
• منشور في: Wiley, 2024-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...