Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• প্রধান লেখক: Nhu Truong (লেখক), Andrea L. Cottingham (লেখক), Shruti Dharmaraj (লেখক), Jacob R. Shaw (লেখক), Jackline Joy Martin Lasola (লেখক), Christopher C. Goodis (লেখক), Steven Fletcher (লেখক), Ryan M. Pearson (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wiley, 2024-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...