Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• Main Authors: Nhu Truong (Author), Andrea L. Cottingham (Author), Shruti Dharmaraj (Author), Jacob R. Shaw (Author), Jackline Joy Martin Lasola (Author), Christopher C. Goodis (Author), Steven Fletcher (Author), Ryan M. Pearson (Author)
• Format: Bog
• Udgivet: Wiley, 2024-01-01T00:00:00Z.
• Fag: article
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Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...