Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• Hauptverfasser: Nhu Truong (Verfasst von), Andrea L. Cottingham (Verfasst von), Shruti Dharmaraj (Verfasst von), Jacob R. Shaw (Verfasst von), Jackline Joy Martin Lasola (Verfasst von), Christopher C. Goodis (Verfasst von), Steven Fletcher (Verfasst von), Ryan M. Pearson (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2024-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...