Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• Κύριοι συγγραφείς: Nhu Truong (Συγγραφέας), Andrea L. Cottingham (Συγγραφέας), Shruti Dharmaraj (Συγγραφέας), Jacob R. Shaw (Συγγραφέας), Jackline Joy Martin Lasola (Συγγραφέας), Christopher C. Goodis (Συγγραφέας), Steven Fletcher (Συγγραφέας), Ryan M. Pearson (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wiley, 2024-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...