Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• मुख्य लेखकों: Nhu Truong (लेखक), Andrea L. Cottingham (लेखक), Shruti Dharmaraj (लेखक), Jacob R. Shaw (लेखक), Jackline Joy Martin Lasola (लेखक), Christopher C. Goodis (लेखक), Steven Fletcher (लेखक), Ryan M. Pearson (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...