Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

• Үндсэн зохиолчид: Nhu Truong (Зохиогч), Andrea L. Cottingham (Зохиогч), Shruti Dharmaraj (Зохиогч), Jacob R. Shaw (Зохиогч), Jackline Joy Martin Lasola (Зохиогч), Christopher C. Goodis (Зохиогч), Steven Fletcher (Зохиогч), Ryan M. Pearson (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Wiley, 2024-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...