Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling

• Egile Nagusiak: Bingbing Shen (Egilea), Mei Mei (Egilea), Youmin Pu (Egilea), Huhai Zhang (Egilea), Hong Liu (Egilea), Maozhi Tang (Egilea), Qianguang Pan (Egilea), Yue He (Egilea), Xiongfei Wu (Egilea), Hongwen Zhao (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2019-09-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Necroptosis, oxidative stress, and inflammation are major contributors to the pathogenesis of ischemic acute kidney injury. Necrostatin-1 (Nec-1), an inhibitor of the kinase domain of receptor-interacting protein kinase-1 (RIP1), has been reported to regulate renal ischemia and reperfusion (I/R) inj...