Necrostatin-1 Attenuates Renal Ischemia and Reperfusion Injury via Meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling

• Main Authors: Bingbing Shen (Author), Mei Mei (Author), Youmin Pu (Author), Huhai Zhang (Author), Hong Liu (Author), Maozhi Tang (Author), Qianguang Pan (Author), Yue He (Author), Xiongfei Wu (Author), Hongwen Zhao (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Necroptosis, oxidative stress, and inflammation are major contributors to the pathogenesis of ischemic acute kidney injury. Necrostatin-1 (Nec-1), an inhibitor of the kinase domain of receptor-interacting protein kinase-1 (RIP1), has been reported to regulate renal ischemia and reperfusion (I/R) inj...