Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome.

• Main Authors: Monica Chandra (Author), Sara Đaković (Author), Konstantina Foti (Author), Johan P Zeelen (Author), Monique van Straaten (Author), Francisco Aresta-Branco (Author), Eliane Tihon (Author), Nicole Lübbehusen (Author), Thomas Ruppert (Author), Lucy Glover (Author), F Nina Papavasiliou (Author), C Erec Stebbins (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigenically distinct copies. The parasite is transferre...