Structural similarities between the metacyclic and bloodstream form variant surface glycoproteins of the African trypanosome.

• मुख्य लेखकों: Monica Chandra (लेखक), Sara Đaković (लेखक), Konstantina Foti (लेखक), Johan P Zeelen (लेखक), Monique van Straaten (लेखक), Francisco Aresta-Branco (लेखक), Eliane Tihon (लेखक), Nicole Lübbehusen (लेखक), Thomas Ruppert (लेखक), Lucy Glover (लेखक), F Nina Papavasiliou (लेखक), C Erec Stebbins (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2023-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

During infection of mammalian hosts, African trypanosomes thwart immunity using antigenic variation of the dense Variant Surface Glycoprotein (VSG) coat, accessing a large repertoire of several thousand genes and pseudogenes, and switching to antigenically distinct copies. The parasite is transferre...