Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish

• Main Authors: Prakash C. Thakur (Author), Jon M. Davison (Author), Carsten Stuckenholz (Author), Lili Lu (Author), Nathan Bahary (Author)
• Format: Book
• Published: The Company of Biologists, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dysregulated phosphatidylinositol (PI) signaling has been implicated in human gastrointestinal (GI) malignancies and inflammatory states, underlining the need to study pathophysiological roles of PI in an in vivo genetic model. Here, we study the significance of PI in GI pathophysiology using the ze...