Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity

• Main Authors: Satoshi Uchida (Author), Kazunori Kataoka (Author), Keiji Itaka (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2015-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Chemical modification of nucleosides in mRNA is an important technology to regulate the immunogenicity of mRNA. In this study, various previously reported mRNA formulations were evaluated by analyzing in vitro protein expression and immunogenicity in multiple cell lines. For the macrophage-derived c...