Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity

Chemical modification of nucleosides in mRNA is an important technology to regulate the immunogenicity of mRNA. In this study, various previously reported mRNA formulations were evaluated by analyzing in vitro protein expression and immunogenicity in multiple cell lines. For the macrophage-derived c...

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Bibliographic Details
Main Authors: Satoshi Uchida (Author), Kazunori Kataoka (Author), Keiji Itaka (Author)
Format: Book
Published: MDPI AG, 2015-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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