Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

• Glavni autori: Atilla Akdemir (Autor), Andrea Angeli (Autor), Füsun Göktaş (Autor), Pınar Eraslan Elma (Autor), Nilgün Karalı (Autor), Claudiu T. Supuran (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Inhibition of the β-carbonic anhydrase (CA, EC 4.2.1.1) from pathogenic Candida glabrata (CgNce103) by 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazones] 4a-m was investigated. All the compounds were found to be potent inhibitors of CgNce103, with inhibition constants in the range of 6....