High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods

• मुख्य लेखकों: Joan Marc Cabot (लेखक), Xavier Subirats (लेखक), Elisabet Fuguet (लेखक), Martí Rosés (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: International Association of Physical Chemists (IAPC), 2014-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In 1997 Valkó et al. developed a generic fast gradient HPLC method, based on the calculation of the chromatographic hydrophobicity index (CHI) from the gradient retention times, in order to measure lipophilicity. We have enhanced the correlations between CHI and log Po/w and adapted the rapid gradie...