High throughput determination log Po/w/pKa/log Do/w of drugs by combination of UHPLC and CE methods

• Prif Awduron: Joan Marc Cabot (Awdur), Xavier Subirats (Awdur), Elisabet Fuguet (Awdur), Martí Rosés (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: International Association of Physical Chemists (IAPC), 2014-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

In 1997 Valkó et al. developed a generic fast gradient HPLC method, based on the calculation of the chromatographic hydrophobicity index (CHI) from the gradient retention times, in order to measure lipophilicity. We have enhanced the correlations between CHI and log Po/w and adapted the rapid gradie...